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A derivative of NNEI in which a fluorine atom has been added to the terminal carbon of the pentyl chain; intended for forensic and research applications
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PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity.
Can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system.
Affects the expression of Mcl-1, a downstream protein of B-Raf.
Induces apoptosis in MCF-7 cells, with an apoptosis rate of 76.70% (64.00% early apoptosis, 12.70% late apoptosis) after 24 h incubation at 20 μM.
Arrests cell cycle at the G2/M phase.
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An alkaloid with anti-inflammatory activity reduces LPS-induced TNF-a release from and NO production in RAW 264.7 macrophages at 10 30 and 100 UM reduces paw swelling in a rat model of CFA-induced arthritis at 9 and 27 mg/kg reduces colonic inflammatory cytokine levels and maintains mucosal barrier function in a mouse model of DSS-induced colitis from 25-100 mg/kg
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RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor that exhibits antitumor activity. It demonstrates a KD of 5.0 μM-15 μM for cyclophilin A (CYPA) binding affinity. This compound is intended for research use only.
Potent RAS and RAS-RAF inhibitor
Exhibits antitumor activity
Has a KD of 5.0 μM-15 μM for cyclophilin A (CYPA) binding affinity
Shows EC50 of 0.5 μM-5.0 μM for BRAF-GTP-KRAS-G12C disruption in H358 cells
Demonstrates IC50 of 1.0 μM-10 μM for pERK inhibition in H358 cells
For research use only
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bio-World's GST-Tagged Protein Purification Buffer Kit consists of a set of buffers necessary for OnePass™ GST-Tagged Recombinant Protein Purification System(Glutathione-Separopore conveniently prepacked spin columns for gravity flow chromatography) or batch purification using Glutathione Separopore.Kit Contents:• GST Binding Buffer (100 ml)• Wash Buffer (200ml)• GST Elution Buffer (50ml)
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The R-PLEX Human Alpha GST Assay Kit from Meso Scale Discovery measures alpha glutathione S-transferase (GSTA1) in human serum plasma and other samples It uses MSD s electrochemiluminescent detection for high sensitivity a dynamic range of up to 5 logs and low sample volume The kit includes a 96-well plate with capture antibodies detection antibodies calibrators controls 10X Read Buffer 10X Wash Buffer and Plate Seals It quantifies alpha GST levels between 0 04 - 500 ng/mL with just 25 L of sample enabling accurate quantitation of the liver toxicity biomarker alpha GST
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